diff --git a/.azure-pipelines/azure-pipelines.yml b/.azure-pipelines/azure-pipelines.yml
index a21a1ef8..3fc5535c 100644
--- a/.azure-pipelines/azure-pipelines.yml
+++ b/.azure-pipelines/azure-pipelines.yml
@@ -62,6 +62,17 @@ stages:
               test: 'devel/sanity/1'
             - name: Units
               test: 'devel/units/1'
+  - stage: Ansible_2_21
+    displayName: Sanity & Units 2.21
+    dependsOn: []
+    jobs:
+      - template: templates/matrix.yml
+        parameters:
+          targets:
+            - name: Sanity
+              test: '2.21/sanity/1'
+            - name: Units
+              test: '2.21/units/1'
   - stage: Ansible_2_20
     displayName: Sanity & Units 2.20
     dependsOn: []
@@ -116,6 +127,25 @@ stages:
           groups:
             - 4
             - 5
+  - stage: Docker_2_21
+    displayName: Docker 2.21
+    dependsOn: []
+    jobs:
+      - template: templates/matrix.yml
+        parameters:
+          testFormat: 2.21/linux/{0}
+          targets:
+            - name: Fedora 43
+              test: fedora43
+            # - name: Ubuntu 22.04
+            #   test: ubuntu2204
+            - name: Ubuntu 24.04
+              test: ubuntu2404
+            # - name: Alpine 3.23
+            #   test: alpine323
+          groups:
+            - 4
+            - 5
   - stage: Docker_2_20
     displayName: Docker 2.20
     dependsOn: []
@@ -207,6 +237,24 @@ stages:
             - 3
             - 4
             - 5
+  - stage: Remote_2_21
+    displayName: Remote 2.21
+    dependsOn: []
+    jobs:
+      - template: templates/matrix.yml
+        parameters:
+          testFormat: 2.21/{0}
+          targets:
+            - name: RHEL 10.1
+              test: rhel/10.1
+            # - name: RHEL 9.7
+            #   test: rhel/9.7
+          groups:
+            - 1
+            - 2
+            - 3
+            - 4
+            - 5
   - stage: Remote_2_20
     displayName: Remote 2.20
     dependsOn: []
@@ -262,14 +310,17 @@ stages:
     condition: succeededOrFailed()
     dependsOn:
       - Ansible_devel
+      - Ansible_2_21
       - Ansible_2_20
       - Ansible_2_19
       - Ansible_2_18
       - Remote_devel
+      - Remote_2_21
       - Remote_2_20
       - Remote_2_19
       - Remote_2_18
       - Docker_devel
+      - Docker_2_21
       - Docker_2_20
       - Docker_2_19
       - Docker_2_18
diff --git a/README.md b/README.md
index a4d35f24..12bb0a97 100644
--- a/README.md
+++ b/README.md
@@ -38,7 +38,7 @@ For more information about communication, see the [Ansible communication guide](
 
 ## Tested with Ansible
 
-Tested with the current ansible-core 2.17, ansible-core 2.18, and ansible-core 2.19 releases, and the current development version of ansible-core. Ansible/ansible-base versions before 2.17.0 are not supported.
+Tested with the current ansible-core 2.17, ansible-core 2.18, ansible-core 2.19, ansible-core 2.20, ansible-core 2.21 releases, and the current development version of ansible-core. Ansible/ansible-base versions before 2.17.0 are not supported.
 
 ## External requirements
 
diff --git a/antsibull-nox.toml b/antsibull-nox.toml
index f8bfdad6..71013955 100644
--- a/antsibull-nox.toml
+++ b/antsibull-nox.toml
@@ -172,6 +172,22 @@ ansible_core = "2.20"
 target = [ "azp/1/", "azp/2/", "azp/3/", "azp/4/", "azp/5/" ]
 remote = [ "rhel/9.7" ]
 
+# Ansible-core 2.21:
+
+[[sessions.ansible_test_integration.groups]]
+session_name = "ansible-test-integration-2.21"
+description = "Meta session for running all ansible-test-integration-2.21-* sessions."
+
+[[sessions.ansible_test_integration.groups.sessions]]
+ansible_core = "2.21"
+target = [ "azp/4/", "azp/5/" ]
+docker = [ "fedora43", "ubuntu2404" ]
+
+[[sessions.ansible_test_integration.groups.sessions]]
+ansible_core = "2.21"
+target = [ "azp/1/", "azp/2/", "azp/3/", "azp/4/", "azp/5/" ]
+remote = [ "rhel/10.1" ]
+
 # Ansible-core devel:
 
 [[sessions.ansible_test_integration.groups]]
diff --git a/tests/sanity/ignore-2.22.txt b/tests/sanity/ignore-2.22.txt
new file mode 100644
index 00000000..21f0cf41
--- /dev/null
+++ b/tests/sanity/ignore-2.22.txt
@@ -0,0 +1,19 @@
+plugins/connection/docker.py no-assert
+plugins/connection/docker_api.py no-assert
+plugins/connection/nsenter.py no-assert
+plugins/module_utils/_api/credentials/store.py pylint:ansible-bad-function
+plugins/module_utils/_api/transport/sshconn.py no-assert
+plugins/module_utils/_api/transport/sshconn.py pylint:ansible-bad-function
+plugins/module_utils/_api/utils/build.py no-assert
+plugins/module_utils/_module_container/module.py no-assert
+plugins/module_utils/_platform.py no-assert
+plugins/module_utils/_socket_handler.py no-assert
+plugins/modules/docker_container_copy_into.py no-assert
+plugins/modules/docker_container_copy_into.py validate-modules:undocumented-parameter # _max_file_size_for_diff is used by the action plugin
+plugins/modules/docker_container_exec.py no-assert
+plugins/modules/docker_image.py no-assert
+plugins/modules/docker_image_tag.py no-assert
+plugins/modules/docker_login.py no-assert
+plugins/modules/docker_plugin.py no-assert
+plugins/modules/docker_swarm_service.py no-assert
+plugins/modules/docker_volume.py no-assert
diff --git a/tests/sanity/ignore-2.22.txt.license b/tests/sanity/ignore-2.22.txt.license
new file mode 100644
index 00000000..edff8c76
--- /dev/null
+++ b/tests/sanity/ignore-2.22.txt.license
@@ -0,0 +1,3 @@
+GNU General Public License v3.0+ (see LICENSES/GPL-3.0-or-later.txt or https://www.gnu.org/licenses/gpl-3.0.txt)
+SPDX-License-Identifier: GPL-3.0-or-later
+SPDX-FileCopyrightText: Ansible Project